The aging process and the ‘7-year Itch.’ Reflections on senescence from the summit of Mt. Colden

The science of aging paints a picture of a progressive, predictable decline of biological function. One topic that always came up during the traditional Tuesday morning science conference at the Orentreich Foundation was the question of whether we age, like all the graphs typically showed, in a mostly sigmoidal S-shaped mode. But hardly anything even in my own life I can consider linear or sigmoidal. Can we instead age in steps rather than a slope of a curve? For some inexplicable reason, this question followed me long after I have gone on to other things and I want to revisit that issue one more time.

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